Dietary Supplement (Proprietary Food Supplement)
Mankind has been consistently trying to fight ageing and its concomitant disease processes-atherosclerosis, cancers, Alzheimer's disease, arthritis, metabolic disorders and others. As we go deeper into the pathogenesis of these processes, many common factors emerge and we realize for instance, that a healthy diet and regular physical exercise are important measures to prevent almost all such disease processes and perhaps ageing itself.Similarly, some nutraceuticals are now being scientifically validated as important components of prevention and management of these disease processes and ageing. One such substance which is the subject of maximum research is curcumin(so much so as to be nick named curecumin). It is the therapeutic principle in turmeric.However,it is present only to the extent of 3% in turmeric and thus for a meaningful therapeutic dose, turmeric consumption alone is not adequate.
Curcumin has been studied and shown effective for a variety of health concerns. It stops pain
and inflammation, inhibits tumors and fights cancer, prevents fat growth and regulates blood
sugar, stops depression and slows the effects of Alzheimer's disease. Curcumin works on
multiple pathways in the body, simultaneously, which accounts for its ability to slow, stop, or
prevent many different disease conditions.
Chronic pain means everything in life requires extra effort. Getting out of bed, walking to the
mailbox, tying your shoes, and opening jars can be frustrating and excruciating. Although
there are many causes of chronic pain past physical injuries, genetics and disease, dietary
or nutritional deficiencies, one thing all forms of chronic pain have in common is inflammation
and cellular damage.
Curcumin Stops Chronic Pain Without Risks Curcumin from turmeric (Curcuma longa) can stop them both. Because curcumin reduces inflammation throughout the body, it is very effective at stopping pain at the source. And, because curcumin also repairs cellular damage and prevents oxidative stress, it can actually heal tissues rather than just mask symptoms.
For example, anyone who has been directly affected by rheumatoid arthritis or knows a
family member or friend who suffers from RA knows how frustrating this condition can be.
This autoimmune disease fools the body into attacking itself, and is normally known for the
damage, inflammation, swelling, and pain is causes in joints. Less well-known is that
rheumatoid arthritis can, in fact, attack anywhere in the body. About 1.5 million Americans
deal with RA, which generally affects women more than men and can start showing
symptoms in some as early as their 20s and 30s.
The immune cells involved in RA include T cells (which can be considered one of three types: helper, killer, and suppressor), and B cells, part of the adaptive immune system that responds to outside threats to the body. Autoimmune diseases like RA show a high activation of these cells, but without any apparent reason.
In any case, they attack the joints and cause serious damage, inflaming the cushioning synovial tissue, and eventually wearing away the structure of the joints altogether if left untreated.
This is partly due to the fact that synovial fluid provides a natural source of a ligand that helps the body properly form new bone tissue. Any disruption to the synovial fluid doesn't just reduce the non-bone joint structure, but the very ability for new healthy bone tissue to form at all.
So far, conventional approaches have had limited value. Treatment typically starts with overthe- counter or prescription anti-inflammatory drugs and may later include other medications that try to modulate the immune system. Unfortunately, these approaches can create problems due to side effects that include stomach damage, susceptibility to infections, and cardiovascular risk.
But curcumin offers a better, natural hope for dealing with the disease. Because it provides such extraordinary benefits for immune system modulation (making sure the immune system responds to real threats in a balanced manner), joint comfort, and protection from oxidative stress, curcumin may be the next advancement in rheumatoid arthritis care.1-7
A published study recently showed that a high-absorption curcumin (important to note, because standard curcumin extracts can be poorly absorbed and utilized) was actually considered superior to the prescription rheumatoid arthritis drug, diclofenac sodium.8 This 8-week study followed 45 subjects, randomized to three groups. All study participants had been diagnosed with rheumatoid arthritis, functional class I or II. Group one received diclofenac sodium, 50 mg, twice daily; group two received 500 mg of high-absorption curcumin twice daily; and group three received both diclofenac sodium and high-absorption curcumin. In the curcumin groups, there were no drop outs due to adverse effects, but in the diclofenac sodium group, 14% withdrew due to adverse effects.
Laboratory studies on kidney and liver function, blood sugar, and a complete blood count were performed before and after participation. There were no significant changes in these measurements in general in all the groups. One laboratory analysis adverse event was reported in the drug (diclofenac sodium) group.
In the Disease Activity Score (“DAS 28”) assessment, high-absorption curcumin had the highest impact for reducing disease symptoms, followed by the combination therapy of curcumin with diclofenac sodium. Interestingly, the diclofenac sodium-alone group scored in last place.
The curcumin group also showed improvement over others in reducing C-reactive protein (CRP) a measure of chronic inflammation, and anti-streptococcal antibodies (ASO) titers, which are associated with severity of rheumatoid arthritis activity. Certainly, part of the reason for curcumin's success was due to its ability to relieve pain by reducing inflammation. But unlike the prescription diclofenac sodium, a non-steroidal antiinflammatory drug, curcumin doesn't damage the lining of the stomach, endanger the liver, or negatively interact with other medications. Beyond that, curcumin will help actually heal the damaged tissue and help reverse the inflammatory damage. So it is doing much more than relieving pain, as important as that is.
Osteoarthritis is marked by intense pain caused by inflammation in the joints throughout the
body. In this degenerative joint disease, the cushioning cartilage that normally absorbs
weight-bearing shocks wears down, eventually causing damage to the ligaments and bones
in the joints as well.
Osteoarthritis and Curcumin Most conventional treatment consists of fighting pain. But this is where complications set in. The inflammation the trigger for the pain is caused by the release of hormone-like compounds called prostaglandins, especially PGE2.
It is sustained by the inflammatory enzyme known as cyclooxygenase-2, or simply COX-2. Interestingly, inflammatory COX-2 enzymes are noted in high concentrations around cancer cells, showing how influential and damaging - inflammation is to health overall. In fact, controlling the COX-2 enzyme could be a possible route to controlling cancer.
As it happens, aspirin use inhibits COX-2, and as a result, aspirin users have less cancer. Unfortunately, aspirin also inhibits COX-1, another enzyme that protects blood vessels and the lining of the digestive tract. Lose that COX-1 protection, and you may get ulcers and weakened blood vessels.
The more powerful prescription COX-2 inhibiting drugs, including Vioxx®, Bextra®, (now both off the market), Celebrex®, and others initially showed no signs of stomach or blood vessel damage. Unfortunately, it was only learned later that these drugs caused strokes and heart attacks because they caused blood clotting.
Curcumin, on the other hand, inhibits the COX-2 enzyme without damaging the stomach lining or blood vessels. In fact, because it stops inflammation and cellular damage, it has been seriously investigated for pain relief from many causes. In one clinical study, an enhanced form of curcumin was evaluated with another traditional Indian botanical, boswellia (Boswelliaserrata), in individuals with osteoarthritis. It compared these two herbal ingredients to a generic form of celecoxib (known under the brand name of Celebrex®).
One group received celecoxib, 100 mg, twice daily. The other group received a 500 mg blend of a specialized, low-beta boswellia and the high-absorption. (The boswellia used in the study had reduced levels of beta-boswellic acid, which can interfere with the plant's otherwise beneficial anti-inflammatory 5-LOX enzyme inhibition.) The results of the study were very strong in favor of the botanicals. For pain relief, 64% of those taking the herbal ingredients (versus 29% in the drug group) improved from “moderate to severe arthritis” to “mild to moderate arthritis.”9 One group received celecoxib, 100 mg, twice daily.
The other group received a 500 mg blend of a specialized, low-beta boswellia and the high-absorption. (The boswellia used in the study had reduced levels of beta-boswellic acid, which can interfere with the plant's otherwise beneficial anti-inflammatory 5-LOX enzyme inhibition.)
Curcumin, due to its poor solubility, high metabolism and bad pharmacokinetics, loses its
efficacy in efficient treatment of the disorders.
To increase the productive use of curcumin, nanotechnology is being considered a potential
Nanocurcumin is a modified form of curcumin in which the particles of curcumin are transformed into nanoparticles that are more soluble and deliverable in the body. These particles have been shown to be more targeted to the tissue of interest that leads to better drug delivery and faster treatment without any wastage or side effects.
.- Consult a health care practitioner prior to use if you are pregnant.
(ESCOP 2003, Brinker 2001, McGuffin et al. 1997)
- Consult a health care practitioner prior to use if you are taking antiplatelet medication
or blood thinners (Mills and Bone 2005, Brinker 2001)
- Consult a health care practitioner prior to use if you have gallstones or a bile duct
obstruction. (ESCOP 2003, Brinker 2001, McGuffin et al. 1997)
- Consult a health care practitioner prior to use if you have stomach ulcers or excess
stomach acid. (Brinker 2001, McGuffin et al. 1997)
- Relief of joint inflammation :
Consult a health care practitioner if symptoms persist or worsen.